Beilstein J. Org. Chem.2021,17, 1–10, doi:10.3762/bjoc.17.1
knowledge of protein–protein interactions, common characterisationmethods to characterise them, and their role in protein complex formation with some examples. A deep understanding of protein–protein interactions and their molecular interactions is important for a number of applications, including drug
design. Protein–protein interactions and their discovery are thus an interesting avenue for understanding how protein complexes, which make up the majority of proteins, work.
Keywords: characterisationmethods; heterooligomeric complex; homooligomeric complex; molecular interactions; protein–protein
], therapeutic interventions [8], and are crucial for potential drug discoveries [9]. This minireview will give a short insight into the different characterisationmethods to characterise PPIs. Moreover, it will provide an examination of the different molecular interactions of PPIs and their role in protein
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Graphical Abstract
Figure 1:
Different methodologies employed to study PPIs. The protein used for illustration is the heterodime...